BDBM50400047 BIIB-057::CHEMBL2177736::US9579320, Example 87

SMILES N[C@H]1CCCC[C@H]1Nc1ncc(C(N)=O)c(Nc2cccc(c2)-n2nccn2)n1

InChI Key InChIKey=TXGKRVFSSHPBAJ-JKSUJKDBSA-N

Data  36 IC50

PDB links: 3 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50400047   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Portola Pharmaceuticals

US Patent

LigandBDBM50400047(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)Copy SMILESCopy InChI

Affinity DataIC50:  300nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
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Ligand InfoPurchaseCHEMBLMCE
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In DepthDetails US Patent
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